Medications & Premature Ejaculation (PE) | menMD

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Medications for Premature Ejaculation

‘Off-label’ oral medications may be prescribed for the treatment of PE. In this case, off-label means these medications use FDA approved ingredients, have been historically prescribed for PE, but are not cleared by the FDA for the treatment of PE. They include antidepressants, analgesics and phosphodiesterase-5 inhibitors. These medications might be prescribed for on-demand use prior to sexual activity or daily use, and may be prescribed alone or in combination with other treatments.


Particular antidepressants may help delay orgasm. Selective serotonin reuptake inhibitors (SSRIs), such as escitalopram (Lexapro), sertraline (Zoloft), paroxetine (Paxil) or fluoxetine (Prozac, Sarafem), may be used to help delay male climax. These are usually prescribed as daily dose medications and may take up to three weeks before realizing benefits. If SSRIs don’t improve your climax control, your healthcare provider may prescribe the tricyclic antidepressant like clomipramine (Anafranil). Unwanted side effects of antidepressants might include nausea, perspiration, drowsiness and decreased libido.


Tramadol also has the side effect of delaying ejaculation. Tramadol is commonly used to treat pain. If SSRIs are not effective your healthcare provider may prescribe Tramadol. Side effects might include nausea, headache, sleepiness, and dizziness. Tramadol can’t be combined with SSRIs.


Phosphodiesterase-5 inhibitors (or PDE5i) are oral medications used to treat erectile dysfunction like sildenafil (Viagra), tadalafil (Cialis) or vardenafil (Levitra), which may also help with PE. Side effects may include headache, facial flushing, and indigestion.

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Available Options

Sildenafil Tablets


Available in 20mg and 100mg tablets.

Sildenafil is the active ingredient in Viagra®

Tadalafil Lozenges


Available in 5mg and 20mg tablets or lozenges.

Tadalafil is the active ingredient in Cialis®

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